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Tiotropium

Tiotropium is an inhaled antimuscarinic bronchodilator used to keep the airways open in chronic obstructive pulmonary disease and asthma. Its effect lasts a full day, so it is taken as regular maintenance therapy and not for sudden breathlessness. The Tiotropium Inhaler is a 9 microgram device.

Medicine containing Tiotropium

Tiotropium Inhaler

Chronic Obstructive Pulmonary Disease, Asthma

9mcg

Tiotropium inhaler is used for chronic obstructive pulmonary disease and asthma. It comes in a single strength, pack sizes vary. You can compare the price per inhaler across options.

FromUS$38.25/ inhalerView

Key points

  • A long-acting muscarinic antagonist (LAMA) in the antimuscarinic class, used for maintenance rather than as a rescue medicine.
  • Labelled for long-term, once-daily treatment of bronchospasm in COPD, including chronic bronchitis and emphysema.
  • Also labelled to reduce exacerbations in COPD, a benefit separate from day-to-day symptom control.

What it is used for

Tiotropium is used for long-term control of airflow obstruction rather than for quick relief. In chronic obstructive pulmonary disease the aim is to ease persistent airway narrowing and lower the frequency of flare-ups; the same ingredient is also used in asthma. Both fall within the respiratory health range. Keeping the bronchi open makes ordinary daily activity less of a strain when breathing is chronically limited.

How it works

The medicine binds to muscarinic receptors on the smooth muscle surrounding the airways. That block interrupts the narrowing signal, so the muscle stays relaxed and the bronchial tubes remain open. Binding is prolonged: bronchodilation begins within about 30 minutes and holds for around 24 hours.

Forms and the inhaler

Tiotropium is made as an inhalation powder and as an inhalation solution. The Tiotropium Inhaler is supplied as an inhaler, taken through the mouth so the medicine reaches the airways directly. Correct technique matters for getting the dose into the lungs, so follow the instructions that come with the device. Orders reach Malaysia from pharmacy partners in India in discreet packaging.

Safety

Do not use tiotropium if you are hypersensitive to it, or to atropine and its derivatives. It is not a treatment for acute bronchospasm; if breathing worsens suddenly, this inhaler will not help. Keep the powder out of your eyes, and use it cautiously in prostatic hyperplasia. People with moderate to severe renal impairment need close monitoring for anticholinergic effects. Paradoxical bronchospasm and glaucoma both require immediate medical attention; if paradoxical bronchospasm occurs, the medicine should be stopped and other treatments considered.

Common minor effects include dry mouth, cough and pharyngitis. Constipation, gastro-oesophageal reflux, tachycardia and blurred vision are also reported. Tiotropium may add to the effects of other anticholinergic medicines, and the label advises against using them together. Use in pregnancy and breastfeeding is with caution, and paediatric use should be discussed with a specialist.

What the sources say

  • Tiotropium bromide is a long-acting inhaled anticholinergic taken once daily for maintenance in COPD (DailyMed).
  • It is not a rescue medication and is not intended for acute use (DailyMed).
  • Patients with moderate to severe renal impairment should be watched closely for anticholinergic side effects (DailyMed).

Further reading

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