Sacubitril
Sacubitril is a neprilysin inhibitor used in the treatment of heart failure. It is not taken on its own: it is combined with valsartan in a single tablet. The two ingredients are used together alongside other medicines.
Medicine containing Sacubitril
Key points
- Sacubitril with valsartan is used with other medicines to lower the risk of death and hospitalisation in adults with certain types of heart failure.
- The combination must not be taken during pregnancy, because it may cause death or serious injury to the fetus in the last 6 months of pregnancy.
- Dizziness, lightheadedness and fainting can occur when getting up quickly from lying down, and this is more common when treatment is first started.
What sacubitril is used for
Sacubitril is used for heart failure, and it is given together with valsartan rather than alone. The heart failure page covers the condition itself, and valsartan has a separate ingredient page.
How it works
Valsartan blocks the action of certain natural substances that tighten blood vessels. Blood then flows more smoothly and the heart can pump more efficiently. Sacubitril belongs to the neprilysin inhibitor class, and the two ingredients act in different ways.
Forms and brands
Entresto tablets contain sacubitril and valsartan together, in a strength of 97/103mg, for heart failure. Pharmacy partners in India ship to Malaysia in discreet packaging.
Safety
Tell your doctor if you are pregnant or plan to become pregnant. Do not take the combination if you are pregnant. If you become pregnant while taking it, stop and call your doctor immediately. Breastfeeding is not recommended while taking valsartan and sacubitril.
What the sources say
- Sacubitril is a neprilysin inhibitor, and it works to help control blood volume (MedlinePlus).
- Rash, itching, swelling of the lips, tongue, face or throat, and difficulty breathing are serious side effects that need immediate medical attention (MedlinePlus).
Further reading
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